Ashitaba

Angelica Keiskei

Use with CautionDigestive HealthImmune SupportMetabolic Health

Medicinal Facts

Angelica keiskei, commonly known as Ashitaba, is rich in chalcones such as xanthoangelol and 4-hydroxyderricin, which are central to its medicinal properties. It bridges the traditional Japanese Kampo medicine, where it is used for vitality and digestion, and modern research focusing on its anti-inflammatory and metabolic effects. Ashitaba's unique compounds interact with various signaling pathways, including AMPK and NF-kB, offering potential benefits for metabolic health and inflammation. Its broad spectrum of activity is complemented by its role in promoting longevity through sirtuin activation.

What it helps with

Metabolic syndrome

Xanthoangelol and 4-hydroxyderricin activate AMP-activated protein kinase (AMPK), which enhances glucose uptake and fatty acid oxidation. This action improves insulin sensitivity and reduces hepatic lipogenesis, as demonstrated in animal studies and preliminary human trials.

Longevity & cellular aging

Ashitaba's chalcones, particularly xanthoangelol, are shown to activate sirtuin 1 (SIRT1), a key regulator of cellular aging. This activation promotes mitochondrial biogenesis via PGC-1a and may enhance telomere maintenance, although human evidence is still emerging.

Chronic inflammation

The chalcones inhibit the NF-kB pathway, reducing the expression of pro-inflammatory cytokines such as TNF-a and IL-6. This mechanism has been observed in vitro and in animal models, suggesting potential benefits for inflammatory conditions.

Cardiovascular health

Ashitaba compounds enhance endothelial nitric oxide synthase (eNOS) activity, improving vasodilation and reducing blood pressure. Animal studies suggest these effects might translate into cardiovascular protection, though more human trials are needed.

Digestive health

Traditionally, Ashitaba is used to support digestion and liver health. Its chalcones stimulate bile secretion and protect hepatocytes, potentially through Nrf2-mediated antioxidant pathways, as seen in preclinical studies.

Neuroprotection

Ashitaba's compounds cross the blood-brain barrier and may reduce neuroinflammation. They are thought to enhance brain-derived neurotrophic factor (BDNF) levels, supporting cognitive health, although human data are limited.

Immune support

The immunomodulatory effects of Ashitaba are attributed to its ability to modulate NF-kB and enhance macrophage activity, as shown in vitro. This suggests a role in supporting immune function, though clinical evidence is sparse.

Key active compounds

Xanthoangelol

A chalcone that activates AMPK and SIRT1, influencing metabolic and longevity pathways. It also inhibits NF-kB, contributing to its anti-inflammatory effects.

4-Hydroxyderricin

Another chalcone with similar properties to xanthoangelol, enhancing AMPK activity and exhibiting strong anti-inflammatory actions through NF-kB inhibition.

Chlorogenic acid

A polyphenol that contributes to Ashitaba's antioxidant capacity by scavenging free radicals and modulating glucose metabolism.

Quercetin

A flavonoid that supports cardiovascular health by enhancing eNOS activity and reducing oxidative stress. It synergizes with other compounds for enhanced bioactivity.

Coumarins

Compounds that may contribute to Ashitaba's anticoagulant and vasodilatory effects, though their specific mechanisms in this context are less studied.

Polysaccharides

Water-soluble components with potential immunomodulatory effects, enhancing macrophage activation and cytokine production in preliminary studies.

What the research says

Research on Ashitaba focuses heavily on its metabolic and anti-inflammatory properties. Chalcones like xanthoangelol and 4-hydroxyderricin are central, with strong preclinical evidence supporting AMPK activation and NF-kB inhibition. Human studies are emerging, particularly in metabolic syndrome contexts, but remain limited. The main challenge is bioavailability, as chalcones are poorly absorbed. Strategies such as nanoparticle formulations and co-administration with bioenhancers are being explored to improve clinical efficacy.

Typical dosage

For tea or infusion, use 1-2 teaspoons of dried leaves per cup of boiling water, steep for 5-10 minutes, and consume up to three times daily. For tinctures, take 10-20 drops diluted in water or juice, up to three times a day. Capsules or powders should be taken according to the manufacturer's instructions, typically around 500 mg to 1 g per day. Fresh juice can be consumed in small amounts, about 30 ml, once daily.

About Ashitaba

Angelica keiskei, commonly known as Ashitaba, is a perennial plant native to Japan, particularly the Izu Islands. It belongs to the Apiaceae family, which includes other well-known herbs such as parsley and celery. Ashitaba is renowned for its vibrant green leaves and yellow sap, which is rich in chalcones, a type of flavonoid with potent antioxidant properties. Traditionally, Ashitaba has been used in Japanese folk medicine for its purported health benefits, including promoting longevity and vitality. It is often consumed as a tea or used in cooking to enhance the nutritional profile of meals. The plant's medicinal properties are largely attributed to its bioactive compounds, such as chalcones, which include xanthoangelol and 4-hydroxyderricin. These compounds are believed to exert anti-inflammatory, antioxidant, and antimicrobial effects. Modern research suggests that Ashitaba may support digestive health by promoting a healthy gut flora and aiding liver detoxification. Additionally, its potential to regulate blood sugar levels makes it a subject of interest for metabolic health studies. While Ashitaba is not as extensively studied as some other medicinal plants, preliminary research indicates its potential in boosting the immune system and providing antiviral benefits. However, its use should be approached with caution, particularly for individuals on anticoagulant medications or those who are pregnant or breastfeeding. As interest in natural remedies grows, Ashitaba continues to be explored for its diverse health-promoting properties.

Traditional Use

Historically, Angelica keiskei has been utilized in traditional Japanese medicine, particularly in the Edo period, where it was celebrated for its health benefits. The name 'Ashitaba' translates to 'tomorrow's leaf,' symbolizing its rapid growth and rejuvenating properties. It has been documented in various herbal texts and is often included in dietary regimens aimed at promoting longevity and vitality. Over time, its use has spread beyond Japan, gaining popularity in other parts of Asia and among health enthusiasts worldwide.

Preparations & Dosage

Preparations

Tea / Infusion: Add 1-2 teaspoons of dried Ashitaba leaves to a cup of boiling water. Allow it to steep for 5-10 minutes. Strain and serve. Optionally, add honey or lemon for taste.
Tincture: Combine fresh or dried Ashitaba leaves with alcohol (such as vodka) in a 1:5 ratio. Seal in a jar and store in a cool, dark place for 4-6 weeks, shaking occasionally. Strain and store in a dark glass bottle.
Capsule: Use commercially prepared Ashitaba capsules. Follow the dosage instructions provided by the manufacturer, typically 500 mg to 1 g per day.

Interactions & Warnings

Angelica keiskei may interact with anticoagulant medications, increasing the risk of bleeding. It should be used cautiously with other herbs that have blood-thinning effects, such as ginkgo biloba and garlic. Individuals with bleeding disorders or those scheduled for surgery should avoid it. High doses may cause gastrointestinal upset or allergic reactions in sensitive individuals.

Use with caution

Angelica keiskei should be used with caution by individuals on blood-thinning medications due to its potential anticoagulant effects. Pregnant or breastfeeding women should avoid it unless advised by a healthcare professional.