Ashitaba

used for dysuria, constipation, poor lactation, and restoration of vitality.

the yellow chalcone-rich sap is pharmacologically distinct from most Apiaceae family members.

Angelica keiskei combats oxidative stress by regulating multiple redox signaling pathways, and its coumarin and flavonoid ingredients have the potential to bind to SIRT3 and SIRT5.
SIRT3 and SIRT5 are mitochondrial sirtuins — two of the core longevity regulators in the sirtuin pathway.
binding and activating mitochondrial sirtuins is one of the most mechanistically direct longevity interventions known from any plant compound.

ashitaba extract patent filed in Japan specifically for hair growth promotion. the mechanism likely involves chalcone-mediated improvement of scalp microcirculation and anti-inflammatory effects at follicle level.

chalcones from ashitaba roots cause artery relaxation through vasorelaxant properties.

laserpitin (a coumarin) improves lipid metabolism in stroke-prone spontaneously hypertensive rats.

chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.

ashitaba suppresses high blood glucose and exerts anti-obesity effects.

4-hydroxyderricin specifically induces caspase-dependent apoptotic cell death in HL60 human leukemia cells. xanthoangelol induces apoptosis in neuroblastoma cells through proteomic-confirmed mechanisms. a chalcone from A. keiskei, 4,4'-dimethoxychalcone, inhibits proliferation of cancer cells by triggering ferroptosis — synergistically activating the Keap1/Nrf2/HO-1 pathway and inhibiting ferrochelatase. ferroptosis is a recently characterized iron-dependent cell death pathway distinct from apoptosis.