Eugenia patrisii

Studies report cytotoxic potential of the essential oil of E. patrisii, rich in E-caryophyllene and bicyclogermacrene, against melanoma, gastric, and colon cancer cells. In cytotoxicity assays, the oil showed activity against HCT-116 colon cancer cells with an IC50 of 16.4 µg/mL.
lower IC50 = more potent.

E-caryophyllene is a CB2 receptor agonist (it binds to the same cannabinoid receptors targeted by cannabis without the psychoactive CB1 pathway).
this compound has shown anti-inflammatory, analgesic, and neuroprotective effects.
E-caryophyllene and caryophyllene oxide are bicyclic sesquiterpene compounds with significant anesthetic, antiproliferative, and cytotoxic effects evaluated in both in vitro and in vivo assays. E. patrisii concentrates this compound at 32% of its leaf oil, making it a high-yield natural source for a cannabinoid-adjacent therapeutic compound, with zero regulatory baggage.

Eugenia species broadly are known for anticonvulsant, antimicrobial, and insecticidal actions.