Bitter Apple

Colocynth (Citrullus colocynthis) is a desert viny plant, also known as bitter apple or wild gourd, native to the Mediterranean and Asia, known for its small, watermelon-like fruit. The fruit contains toxic compounds (cucurbitacins) that cause severe gastrointestinal issues, leading to its ban by the FDA (titanium dioxide in our food is fine though, somehow), but it has traditional uses for conditions like diabetes, constipation, and inflammation, and its seeds are used for oil and food in some cultures. 

is antioxidative, hypoglycemic, antibacterial, anti-cancerous, anti-inflammatory, analgesic, gastrointestinal tract, reproduction, protection, anti-microbial, antidiabetic, hypolipidemic, antineoplastic, profibrinolytic, anti-allergic, pesticidal, and immune-stimulatory. has numerous bioactive compounds like cucurbitacin, flavonoids, and polyphenols.
also has pharmacological properties, such as being a laxative and purgative; it is anti-diabetic, anti-inflammatory, anthelmintic, and anti-cancerous.
an extract showed anti-tumor activity on cancerous cells and its leaves are anti-cancerous and anti-adipogenic.
Creams are made from it for pain relief in joints, muscles, and feet. 
The plant is also used to treat diabetes, liver problems, weak bowel movements, and obstruction or paralysis of the intestine.