MSM

Methylsulfonylmethane (MSM) is an organic sulfur-containing compound found naturally in plants, animals, and humans, though in small amounts.
it is already a trace part of the diet, present in cow's milk, coffee, tomatoes, and green vegetables, and even in rainfall, as part of the earth's natural sulfur cycle.

bioavailable delivery form of sulfur, the mineral your body uses to build cartilage, collagen, keratin, and glutathione. so it gives the body the sulfur it needs to build cartilage.

MSM reduces joint pain and inflammation by downregulating NF-kappaB and lowering IL-6, TNF-alpha, and IL-1-beta, the genes that trigger inflammatory signals.
it also directly inhibits cartilage from breaking down.
consistent results in arthritis studies at 1-3g per day.
works even better paired with glucosamine and chondroitin.

there was a 16-week (human) trial at 1-3g daily, where msm produced significant improvements in facial wrinkles, firmness, skin hydration, elasticity, tone, and texture.

MSM supplies the sulfur that your hair, nails, and skin are literally built from (keratin and collagen).
hair is made primarily of keratin, and keratin needs sulfur to form properly.
it also reduces scalp inflammation, which is a major cause of hair loss.
msm gives better skin firmness and fewer wrinkles, and stronger hair and nails.
good for skin quality and aging, and hair and nail strength.

MSM reduces hay fever and seasonal allergy symptoms (both nasal congestion and lower respiratory symptoms) while also increasing energy levels.

shuts down key growth-signaling pathways (STAT3 and STAT5b) that breast cancer cells use, it made the breast-cancer drug tamoxifen work harder and blocked the tumors from spreading. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033361
MSM was administered orally to mice with genetic predisposition to lymphoma and rheumatoid arthritis. there was a significant delay in development of lymphomas as well as decreased tumor incidence compared with control. in a separate pilot study, female rats given DMBA carcinogen while receiving MSM in their drinking water did not develop tumors, while mammary tumors were seen in control animals. so MSM both prevented lymphoma development and completely blocked mammary tumor formation from a known carcinogen. https://link.springer.com/article/10.1186/s12885-015-1445-0 i dont like adding links because it kinda ruins the flow.

helps shield the liver from toxic damage, including the kind caused by acetaminophen (Tylenol) overdose, largely by restoring the glutathione that the liver burns through when detoxifying such toxins.

MSM lowers the muscle damage, soreness, and oxidative stress that come after intense exercise, so you recover faster and hurt less the next day. good for post-workout recovery, delayed-onset muscle soreness, and athletic joint support. athletes use it to recover faster.

helps to heal the damaged lining of the digestive tract, thus preventing and helping recover from leaky gut syndrome, colitis, and inflammatory bowel diseases.

MSM effectively restored glutathione levels and reduced inflammatory markers in mouse cells that had been weakened with HIV proteins, in a test tube study.

msm will also enhance the absorption of pills you take.
increases cell-membrane permeability (how easily substances cross cell membranes), which is why it both boosts absorption of nutrients taken with it and is added to topical products to carry other actives into the skin.
this is useful, but it means it can also increase the effect or blood level of other drugs, so anyone on prescription medication should account for that.