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C. rotundus contains essential oils and phytochemicals including flavonoids, alkaloids, and saponins contributing to hair-removal properties.
these compounds target hair follicles, dissolve keratin, and inhibit hair regrowth by modulating biological pathways. γ-curcumene has been shown to suppress hair growth.

CREO found as effective as Alexandrite laser treatments in some cases particularly in reducing white hair.

used for hirsutism, atherosclerosis, aging, apoptosis, cancer, cystitis, epilepsy, nociception, and prostatitis disorders.

shown to have antidepressant and neuroprotective properties.
documented AMPK activation (the longevity and energy metabolism pathway) and neuroprotective properties.

α-cyperone induces apoptosis in cancer cell lines through mitochondrial pathway activation. the stilbene fraction adds resveratrol-type antiproliferative activity.

used in TCM for liver disease, stomach pain, breast tenderness, dysmenorrhea, and menstrual irregularities.
combined with the estrogenic activity of certain flavonoid fractions creates a hormonal modulating profile relevant to polycystic ovarian syndrome, dysmenorrhea, and breast tenderness. the anti-estrogenic sesquiterpene fraction provides feedback balance.

nootkatone (isolated from C. rotundus rhizomes) is commercially important as a grapefruit flavor/fragrance compound and is also EPA-registered as a natural insecticide and insect repellent (effective against ticks, mosquitoes, and bed bugs).
nootkatone is currently being developed as an active ingredient in natural insect repellent products as an alternative to DEET.