Gotu Kola

approximately 124 chemical compounds isolated and identified from Centella asiatica. primary bioactive compounds are pentacyclic triterpenoids and trisaccharide derivatives including asiaticoside, brahmoside, asiatic acid, brahmic acid (madecassic acid), centellose, centelloside, and madecassoside.

phytochemicals identified include isoprenoids — sesquiterpenes, plant sterols, pentacyclic triterpenoids and saponins — and phenylpropanoid derivatives including eugenol derivatives, caffeoylquinic acids, and flavonoids.

asiatic acid effectively relieves cognitive impairment, Alzheimer's disease, and Parkinson's disease in preclinical studies. asiaticoside has therapeutic potential for hemiparkinsonism, Alzheimer's disease, and cerebral ischemia. madecassic acid had positive therapeutic effect on ischemic retinopathies.

caffeoylquinic acids from Centella enhance the Nrf2-antioxidant response pathway — a key longevity and cellular stress resistance pathway.

The plant is alterative, tonic, diuretic, antiphlogistic, blood purifier and local stimulant. It is a remedy for skin diseases, like chronic eczema, chronic ulcers, psoriasis, etc., enlargement of glands, chronic rheumatism, chronic nervous diseases, madness, cholera, amenorrhea and piles.

asiatic acid and asiaticoside may slow tumor growth and inhibit cancer cell activity in colon, liver, prostate, and breast cancer.

asiatic acid induces apoptosis through mitochondrial pathways and suppresses NF-κB, with documented activity against hepatocellular carcinoma, lung cancer, and colon carcinogenesis in preclinical models.

madecassoside active in cardiovascular contexts including myocardial ischemia/reperfusion injury, atherosclerosis, and pulmonary hypertension.

The leaves are household remedy in the early stages of dysentery in children.

The powder of leaves is given with milk in small doses in mental weakness and to improve memory.

The fresh juice of leaves mixed with milk is given as an alterative in gonorrhoea, jaundice and fevers; this is also useful for children in skin diseases and for improving the blood and nervous system.

An ointment made of leaf juice and lanoline is of great value in elephantiasis.

heals heal skin and scarring, increases collagen production.

decreases swelling and blood pressure.

facilitates the glymphatic drainage system, effectively removing harmful brain toxins.

extremely similar to brahmi.